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KMID : 0191119970120060570
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Journal of Korean Medical Science
1997 Volume.12 No. 6 p.570 ~ p.575
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Cowden´s disease--a report on the first case in Korea and literature review
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Lee HR
Moon YS/Yeom CH/Kim KW/Chun JY/Kim HK/Choi HS/Kim DK/Chung TS
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Abstract
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Cowden's disease, or multiple hamartoma syndrome, is an uncommon condition with characteristic mucocutaneous lesions associated with abnormalities of the breast, thyroid, and gastrointestinal tract. We describe a 32-year-old man with oral mucosal papillomatosis and plantar hyperkeratosis as a definite case of Cowden's disease according to the criteria proposed by Salem and Steck. The patient also had a thyroid mass and numerous gastrointestinal polyps endoscopically. Histologically the polyps were hamartomatous or hyperplastic polyps. The oral papillary lesions were fibroepithelial polyps and the thyroid mass was a follicular adenoma. We review the literature on this entity and summarize the pertinent findings. To the best of our knowledge, this is the first documented case of Cowden's disease in a Korean.
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